What is TRALI? It is an acronym for Transfusion-related Acute Lung Injury. If you haven't heard much about it, you will soon! Peggy has more education about it in the pipeline. In the meantime...an introduction:
"TRALI should be suspected in all cases of dyspnea and hypoxia temporally related to blood transfusion. Dyspnea due to bronchospasm associated with allergic/anaphylactic reactions can be readily identified based on the accompanying urticarial rash. Dyspnea associated with pulmonary edema after transfusion may result from TRALI or from transfusion-associated circulatory overload (TACO). Differentiation between TACO and TRALI is important from patient treatment and blood donor management perspectives. Recently an algorithm was developed to help eliminate clinicians and researchers in managing patients with respiratory symptoms associated with blood transfusion. Hydrostatic (TACO) and permeability (TRALI) pulmonary edema may coexist. Hence, evaluation by a critical care specialist may be necessary."
Reference: Blood Bulletin, July 2006. Volume 8, No. 2
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